Recently, the international academic journal Small in the form of cover papers published in the Chinese Academy of Sciences, Shenyang Institute of Automation micro-nano research group in micro-nano robotics and biomedical cross areas of the latest achievements High-Throughput Fabrication and Modular Assembly of 3D Heterogeneous Microscale Tissues, ADVANCED SCIENCE NEWS by "micro-organization of 3D bio-manufacturing new method" for the topic of a special report, and for many days in the news reading ranked first. Shenyang Automation scientists and life sciences experts in close exchanges and in-depth cooperation, and actively combine robotics and biomedicine, and strive to open up new areas of application for the robot in the field of new drug research and development. Different from the traditional manufacturing industry, the biomedical field is changed from a structural component to an unstructured living cell, and the operating environment is changed from a normal atmosphere to a physiological liquid environment. This brings forward the perception, drive and control of the robot technology A lot of challenges. The micro-nano research group has actively explored the above problems and has successively implemented the manipulation of micro-tissues, cells and protein molecules in the physiological environment and provided the key technical support for the application of robotics in biomedicine. The paper, published in the cover of Small, focuses on the needs of drug screening for the human micro-organizational environment. Toxicity and drug resistance testing of drugs is a crucial step in the development of new drugs. The existing single-cell screening models have the problems of low efficacy and poor detection of toxicity. The main reason is that it is difficult to accurately simulate single cells Human environment. In response to the above problems, the research group proposed the online manufacturing of micro-organizations and the Organ Real-time Assembly on Chip. Through this method, different types of three-dimensional micro-cellular structures can be manufactured on-line according to the requirements and the micro-nano Robot technology for on-line assembly to form multi-cellular complex tissue-like connectors that are human-like and provide a viable solution for in vitro human-like physiological simulation. In addition, the whole process is realized by robotic automation method, so it has good repeatability and stability, so as to ensure the consistency of human-like physiological environment and lay the foundation for future tissue regeneration and personalized drug screening. Focusing on the interdisciplinary research of micro-nano robots and life sciences, the micro-nano research group has made important progress in personalized cancer treatment, acquisition of multi-dimensional information of cells and creation of advanced instruments. Relevant work has been published in Nature Communications, Lab on a Chip, Langmuir And IEEE Journal, the paper was published on the cover of Soft Matter, Applied Physics Letters, IEEE Nanotechnology Magazine and other journals, and the research results of the micro-nano group were again published on the cover of the academic journals The research layout in the field of micro-nano robot in Shenyang Automation is gradually systematized and systematized, and new progress is continuously made. The innovation capability and the influence at home and abroad have been steadily improved, laying a solid foundation for better future achievements. Journals cover Different kinds of micro-organizational structure of the online assembly
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